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Gold(I)-Catalyzed Domino Ring-Opening Ring-Closing Hydroamination of Methylenecyclopropanes (MCPs) with Sulfonamides: Facile Preparation of Pyrrolidine Derivatives

Min Shi,* Le-Ping Liu and Jie Tang

*State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China, Email:

M. Shi, L.-P. Liu, J. Tang, Org. Lett., 2006, 8, 4043-4046.

DOI: 10.1021/ol0614830 (free Supporting Information)


The gold(I)-catalyzed reaction of methylenecyclopropanes with sulfonamides produces the corresponding pyrrolidine derivatives in moderate to good yields via a domino ring-opening ring-closing hydroamination process.

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ID: J54-Y2006-2540