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Synthesis of Imidazoles through the Copper-Catalyzed Cross-Cycloaddition between Two Different Isocyanides

Chikashi Kanazawa, Shin Kamijo and Yoshinori Yamamoto*

*Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan, Email:

C. Kanazawa, S. Kamijo, Y. Yamamoto, J. Am. Chem. Soc., 2006, 128, 10662-10663.

DOI: 10.1021/ja0617439 (free Supporting Information)


The copper-catalyzed reaction between two different isocyanides produces imidazoles in good yields. The mechanism is discussed.

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Key Words

Imidazoles, Isocyanides

ID: J48-Y2006-2610