A New, Simple Synthesis of N-Tosyl Pyrrolidines and Piperidines
Maria Carla Marcotullio, Valerio Campagna, Silvia Sternativo, Ferdinando Costantino, Massimo Curini
*Dipartimento di Chimica e Tecnologia del Farmaco, Sez, Chimica
Organica-Università degli Studi, 06123 Perugia, Italy, Email: marcotu
unipg.it
M. C. Marcotullio, V. Campagna, S. Sternativo, F. Costantino, M. Curini, Synthesis, 2006, 2760-2766.
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Abstract
Iodocyclization of unsaturated tosylamides promoted by Oxone oxidation of KI afforded, in good yields, N-tosyl iodopyrrolidines and piperidines. A new, simple method for the conversion of alcohols to tosylamides is presented.
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Key Words
pyrrolidines, piperidines, Oxone, iodocyclization, mesylation, nucleophilic substitution, toluenesulfonamides
ID: J66-Y2006-2680
