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Palladium-Catalyzed Dehydrative Allylation of Hypophosphorous Acid with Allylic Alcohols

Karla Bravo-Altamirano and Jean-Luc Montchamp*

*Department of Chemistry, Box 298860, Texas Christian University, Fort Worth, Texas 76129, Email:

K. Bravo-Altamirano, J.-L. Montchamp, Org. Lett., 2006, 8, 4169-4171.

DOI: 10.1021/ol061828e


A novel palladium-catalyzed allylation of H3PO2 with allylic alcohols produces allylic-H-phosphinic acids and water, in the absence of additives. Primary H-phosphinic acids are obtained in excellent yields, whereas secondary H-phosphinic acids react sluggishly.

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proposed mechanism

Key Words

Phosphinic Acids, Tsuji-Trost Reaction

ID: J54-Y2006-2690