Nickel-Catalyzed Cyclization of 2-Iodoanilines with Aroylalkynes: An Efficient Route for Quinoline Derivatives
Rajendra Prasad Korivi and Chien-Hong Cheng*
*Department of Chemistry, National Tsing Hua University, Hsinchu 30013, Taiwan, Email: chchengmx.nthu.edu.tw
R. P. Korivi, C.-H. Cheng, J. Org. Chem., 2006, 71, 7079-7082.
An efficient and convenient nickel-catalyzed cyclization of 2-iodoanilines with alkynyl aryl ketones gives 2,4-disubstituted quinolines. Naturally occurring quinoline derivatives have been prepared in good yields. The mechanism is discussed.
see article for more examples