Aqueous N-Heterocyclization of Primary Amines and Hydrazines with Dihalides: Microwave-Assisted Syntheses of N-Azacycloalkanes, Isoindole, Pyrazole, Pyrazolidine, and Phthalazine Derivatives
Yuhong Ju and Rajender S. Varma*
*Clean Processes Branch, Sustainable Technology Division, National Risk
Management Research Laboratory, U.S. Environmental Protection Agency, 26 West
Martin Luther King Drive, MS 443, Cincinnati, Ohio 45268, Email: Varma.Rajender
epa.gov
Y. Ju, R. S. Varma, J. Org. Chem., 2006, 71, 135-141.
DOI: 10.1021/jo051878h
see article for more examples
Abstract
A one-pot synthesis of nitrogen-containing heterocycles from alkyl dihalides and primary amines and hydrazines occurs under microwave irradiation via a simple and efficient cyclocondensation in an alkaline aqueous medium.
see article for more reactions
see article for more examples
Key Words
Cyclic Amines, Azetidines, Pyrrolidines, Piperidines, Pyrazolines, N-Heterocycles, Microwave Synthesis, Green Chemistry
ID: J42-Y2006-2770
