A Convenient Method for the Conversion of a Carboxy Group into a 4,6-Dimethoxy-1,3,5-triazine Group: Application to N-Benzylpyroglutamic Acids
Souhila Oudir, Benoît Rigo, Jean-Pierre Hénichart, Philippe Gautret*
*Groupe de Recherche sur l'Inhibition de la Prolifération Cellulaire, EA 2692, Ecole des Hautes Etudes d'Ingénieur, 13 rue de Toul, 59046 Lille, France, Email: philippe.gautrethei.fr
S. Oudir, B. Rigo, J.-P. Hénichart, P. Gautret, Synthesis, 2006, 2845-2848.
DOI: 10.1055/s-2006-942519
Abstract
Activated carboxylic acids react with a stoichiometric amount of zinc dimethyl imidodicarbonimidate in CH2Cl2-pyridine with molecular sieves to form 4,6-dimethoxy-1,3,5-triazines in high yields.
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Key Words
triazines, pyroglutamic derivatives, lactams, imidodicarbonimidate zinc salt, heterocycles
ID: J66-Y2006-2780