4,7-Dimethoxy-1,10-phenanthroline: An Excellent Ligand for the Cu-Catalyzed N-Arylation of Imidazoles
Ryan A. Altman and Stephen L. Buchwald*
*Department of Chemistry, Massachusetts Institute of Technology, Cambridge,
Massachusetts 02139, Email: sbuchwal
mit.edu
R. A. Altman, S. L. Buchwald, Org. Lett., 2006, 8, 2779-2782.
DOI: 10.1021/ol0608505
Abstract
4,7-Dimethoxy-1,10-phenanthroline is an efficient ligand for the mild, copper-catalyzed N-arylation of imidazole with aryl iodides and bromides. Various hindered and functionalized imidazoles and aryl halides were transformed in good to excellent yields.
see article for more examples
Copper-Diamine-Catalyzed N-Arylation of Pyrroles, Pyrazoles, Indazoles, Imidazoles, and Triazoles
J. C. Antilla, J. M. Baskin, T. E. Barder, S. L. Buchwald, J. Org. Chem., 2004, 69, 5578-5587.
Key Words
Ullmann Synthesis, N-Arylation
ID: J54-Y2006-2850
