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Efficient Oxidative Synthesis of 2-Oxazolines

Kirsten Schwekendiek, Frank Glorius*

*Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Straße, 35032 Marburg, Germany, Email:

K. Schwekendiek, F. Glorius, Synthesis, 2006, 2996-3002.

DOI: 10.1055/s-2006-950198


New methodology for the synthesis of variously substituted 2-oxazolines and one dihydrooxazine using aldehydes, amino alcohols, and N-bromosuccinimide as an oxidizing agent is described. This one-pot synthesis is characterized by mild reaction conditions, broad scope, high yields, and its preparative simplicity.

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reaction pathway

Key Words

amino alcohols, oxidative coupling, oxazolines, oxazolidines, N-bromosuccinimide

ID: J66-Y2006-2870