Efficient Oxidative Synthesis of 2-Oxazolines
Kirsten Schwekendiek, Frank Glorius*
*Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Straße,
35032 Marburg, Germany, Email: glorius
chemie.uni-marburg.de
K. Schwekendiek, F. Glorius, Synthesis, 2006, 2996-3002.
DOI: 10.1055/s-2006-950198
Abstract
New methodology for the synthesis of variously substituted 2-oxazolines and one dihydrooxazine using aldehydes, amino alcohols, and N-bromosuccinimide as an oxidizing agent is described. This one-pot synthesis is characterized by mild reaction conditions, broad scope, high yields, and its preparative simplicity.
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reaction pathway
Key Words
amino alcohols, oxidative coupling, oxazolines, oxazolidines, N-bromosuccinimide
ID: J66-Y2006-2870
