Efficient Catalytic Insertion of Acetylenes into a Carbon-Carbon Single Bond of Nonstrained Cyclic Compounds under Mild Conditions
Yoichiro Kuninobu,* Atsushi Kawata and Kazuhiko Takai*
*Division of Chemistry and Biochemistry, Graduate School of Natural Science and Technology, Okayama University, Tsushima, Okayama 700-8530, Japan, Email: kuninobucc.okayama-u.ac.jp, ktakaicc.okayama-u.ac.jp
Y. Kuninobu, A. Kawata, K. Takai, J. Am. Chem. Soc., 2006, 128, 11368-11369.
DOI: 10.1021/ja064022i (free Supporting Information)
[ReBr(CO)3(thf)]2 catalyzes the reaction of a 1,3-dicarbonyl cyclic compound with an acetylene to give a medium-sized cyclic compound in excellent yield. By using isocyanide as an additive, the insertion of acetylenes into a carbon-carbon single bond occurs under mild conditions.
see article for more examples
Y. Kuninobu, A. Kawata, K. Takai, Org. Lett., 2005, 7, 4823-4825.