Efficient Synthesis of Functionalized Organozinc Compounds by the Direct Insertion of Zinc into Organic Iodides and Bromides
Arkady Krasovskiy, Vladimir Malakhov, Andrei Gavryushin, Paul Knochel
*Ludwig Maximilians-Universität München, Department Chemie & Biochemie, Butenandtstrasse 5-13, Haus F, 81377 München, Email: paul.knochelcup.uni-muenchen.de
A. Krasovski, V. Malakhov, A. Gavryushin, P. Knochel, Angew. Chem. Int. Ed., 2006, 45, 6040-6044.
DOI: 10.1002/anie.200601450
see article for more reactions
Abstract
The use of Zn powder in the presence of LiCl in THF allows a simple, high-yielding preparation of a broad range of functionalized aryl- and heteroarylzinc reagents. The synthesis of alkylzinc reagents was performed from inexpensive alkyl bromides.
see article for more examples
Highly Stereoselective Cobalt-Catalyzed Allylation of Functionalized Diarylzinc Reagents
G. Dunet, P. Knochel, Synlett, 2007, 1383-1386.
Key Words
coupling (acylation of arenes, acylations, allylation), homogeneous catalysis, insertion, organozinc compounds, zinc
ID: J06-Y2006-2970