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A One-Pot Preparation of 1,3-Disubstituted Azetidines

Michael C. Hillier* and Cheng-yi Chen

*Department of Process Research, Merck & Co., P.O. Box 2000, Rahway, New Jersey 07065, Email: michael_hilliermerck.com

M. C. Hillier, C.-Y. Chen, J. Org. Chem., 2006, 71, 7885-7887.

DOI: 10.1021/jo061147x (free Supporting Information)


Abstract

A straightforward synthesis of various 1,3-disubstituted azetidines has been accomplished via the alkylation of primary amines with in situ generated bis-triflates of 2-substituted-1,3-propanediols.

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Key Words

Azetidines


ID: J42-Y2006-3080