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Stereoselective Synthesis of Functionalized Pyrrolidines via a [3 + 2]-Annulation of N-Ts-α-Amino Aldehydes and 1,3-Bis(silyl)propenes

Per Restorp, Andreas Fischer and Peter Somfai*

*Organic Chemistry and Inorganic Chemistry, KTH Chemical Science and Engineering, 100 44 Stockholm, Sweden, Email: peter.somfaichem.lu.se

P. Restorp, A. Fischer, P. Somfai, J. Am. Chem. Soc., 2006, 128, 12646-12647.

DOI: 10.1021/ja0647102 (free Supporting Information)


Abstract

A [3 + 2]-annulation of N-Ts-α-amino aldehydes and 1,3-bis(silyl)propenes allows an efficient, stereoselective synthesis of densely functionalized pyrrolidines.

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Key Words

Pyrrolidines


ID: J48-Y2006-3190