Organic Chemistry Portal



Gold(I)-Catalyzed Reaction of 1-(1-Alkynyl)-cyclopropyl Ketones with Nucleophiles: A Modular Entry to Highly Substituted Furans

Junliang Zhang, Hans-Günther Schmalz*

*Institut für Organische Chemie, Universität zu Köln, Greinstrasse 4, 50939 Köln, Germany, Email:

J. Zhang, H.-G. Schmalz, Angew. Chem. Int. Ed., 2006, 45, 6704-6707.

DOI: 10.1002/anie.200601252 (free Supporting Information)


A mild, gold-catalyzed cascade reaction provides efficient access to highly substituted furans. The substrates can be readily prepared from the corresponding enones through cyclopropanation.

see article for more examples

Key Words

cyclopropanes, furans, gold, ring expansion, transition metals

ID: J06-Y2006-3270