On Water and in Air: Fast and Highly Chemoselective Transfer Hydrogenation of Aldehydes with Iridium Catalysts
Xiaofeng Wu, Jianke Liu, Xiaohong Li, Antonio Zanotti-Gerosa, Fred Hancock, Daniele Vinci, Jiwu Ruan, Jianliang Xiao*
*Liverpool Centre for Materials and Catalysis, Department of Chemistry,
University of Liverpool, Liverpool L69 7ZD, UK, Email: j.xiao
liv.ac.uk
X. Wu, J. Liu, X. Li, A. Zanotti-Gerosa, F. Hancock, D. Vinci, J. Ruan, J. Xiao, Angew. Chem. Int. Ed., 2006, 45, 6718-6722.
DOI: 10.1002/anie.200602122
see article for more reactions
Abstract
An on-water Ir(III)-diamine catalysis represents an efficient, simple and environmentally friendly catalytic system for the transfer hydrogenation of aldehydes. The catalyst tolerates various synthetically useful groups including nitro groups, halogens, ketones, esters and olefins.
see article for more examples
Accelerated asymmetric transfer hydrogenation of aromatic ketones in water
X. Wu, X. Li, W. Hems, F. King, J. Xiao, Org. Biomol. Chem., 2004, 2, 1818-1821.
Key Words
aldehydes, enones, chemoselectivity, iridium, transfer hydrogenation, formic acid, water, green chemistry
ID: J06-Y2006-3290
