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Convenient Method for the Preparation of Weinreb Amides via Pd-Catalyzed Aminocarbonylation of Aryl Bromides at Atmospheric Pressure

Joseph R. Martinelli, Dominique M. M. Freckmann and Stephen L. Buchwald*

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email:

J. R. Martinelli, D. M. M. Freckmann, S. L. Buchwald, Org. Lett., 2006, 8, 4795-4797.

DOI: 10.1021/ol061902t


A Pd-catalyzed aminocarbonylation of aryl bromides into the corresponding Weinreb amides at atmospheric pressure efficiently transforms eletron-deficient, - neutral, and -rich aryl bromides.

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Key Words

Aminocarbonylation, Weinreb amides

ID: J54-Y2006-3310