Organic Chemistry Portal

Abstracts

Search:

Convenient Method for the Preparation of Weinreb Amides via Pd-Catalyzed Aminocarbonylation of Aryl Bromides at Atmospheric Pressure

Joseph R. Martinelli, Dominique M. M. Freckmann and Stephen L. Buchwald*

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email: sbuchwalmit.edu

J. R. Martinelli, D. M. M. Freckmann, S. L. Buchwald, Org. Lett., 2006, 8, 4795-4797.

DOI: 10.1021/ol061902t (free Supporting Information)


Abstract

A Pd-catalyzed aminocarbonylation of aryl bromides into the corresponding Weinreb amides at atmospheric pressure efficiently transforms eletron-deficient, - neutral, and -rich aryl bromides.

see article for more examples



Key Words

Aminocarbonylation, Weinreb amides


ID: J54-Y2006-3310