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Chemoselective Nucleophilic Arylation and Single-Step Oxidative Esterification of Aldehydes Using Siloxanes and a Palladium-Phosphinous Acid as a Reaction Switch

Rachel Lerebours and Christian Wolf*

*Department of Chemistry, Georgetown University, Washington, D.C. 20057, Email:

R. Lerebours, C. Wolf, J. Am. Chem. Soc., 2006, 128, 13052-13053.

DOI: 10.1021/ja063476c

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Aldehydes and siloxanes form methyl esters in a single step through mild oxidative esterification in the presence of a palladium catalyst or, alternatively, afford secondary alcohols via TBAF-promoted arylation in the absence of a catalyst at increased temperatures.

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Key Words

Oxidative Esterification, 1,2-Addition, Microwave Synthesis

ID: J48-Y2006-3320