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Molecular Iodine-Catalyzed Facile Procedure for N-Boc Protection of Amines

Ravi Varala, Sreelatha Nuvula and Srinivas R. Adapa*

*Indian Institute of Chemical Technology, Hyderabad-500 007, Email: rvarala_iictyahoo.co.in

R. Varala, S. Nuvula, S. R. Adapa, J. Org. Chem., 2006, 71, 8283-8286.

DOI: 10.1021/jo0612473 (free Supporting Information)


Abstract

An efficient and practical protocol allows the protection of various aryl and aliphatic amines using (Boc)2O in the presence of a catalytic amount of iodine under solvent-free conditions at ambient temperature.


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Key Words

tert-butyl carbamates, green chemistry


ID: J42-Y2006-3330