Molecular Iodine-Catalyzed Facile Procedure for N-Boc Protection of Amines
Ravi Varala, Sreelatha Nuvula and Srinivas R. Adapa*
*Indian Institute of Chemical Technology, Hyderabad-500 007, Email: rvarala_iictyahoo.co.in
R. Varala, S. Nuvula, S. R. Adapa, J. Org. Chem., 2006, 71, 8283-8286.
DOI: 10.1021/jo0612473
Abstract
An efficient and practical protocol allows the protection of various aryl and aliphatic amines using (Boc)2O in the presence of a catalytic amount of iodine under solvent-free conditions at ambient temperature.
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Key Words
tert-butyl carbamates, green chemistry
ID: J42-Y2006-3330