Organic Chemistry Portal

Abstracts

Search:

Highly Efficient Oxidative Amidation of Aldehydes with Amine Hydrochloride Salts

Woo-Jin Yoo and Chao-Jun Li*

*Department of Chemistry, McGill University, Montreal, Quebec, Canada H3A 2K6, Email: cj.limcgill.ca

W.-J. Yoo, C.-J. Li, J. Am. Chem. Soc., 2006, 128, 13064-13065.

DOI: 10.1021/ja064315b (free Supporting Information)


Abstract

A mild and efficient oxidative amidation of aldehydes uses amine HCl salts and tert-butyl hydroperoxide as an oxidant in the presence of a copper catalyst.


see article for more examples


proposed mechanism



Key Words

Amination, tert-butyl hydroperoxide


ID: J48-Y2006-3360