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Highly Efficient Oxidative Amidation of Aldehydes with Amine Hydrochloride Salts

Woo-Jin Yoo and Chao-Jun Li*

*Department of Chemistry, McGill University, Montreal, Quebec, Canada H3A 2K6, Email:

W.-J. Yoo, C.-J. Li, J. Am. Chem. Soc., 2006, 128, 13064-13065.

DOI: 10.1021/ja064315b


A mild and efficient oxidative amidation of aldehydes uses amine HCl salts and tert-butyl hydroperoxide as an oxidant in the presence of a copper catalyst.

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proposed mechanism

Key Words

oxidative amidation, tert-butyl hydroperoxide

ID: J48-Y2006-3360