A General and Efficient FeCl3-Catalyzed Nucleophilic Substitution of Propargylic Alcohols
Zhuang-ping Zhan,* Jing-liang Yu, Hui-juan Liu, Yuan-yuan Cui, Rui-feng Yang, Wen-zhen Yang and Jun-ping Li
*Department of Chemistry and The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Email: zpzhanxmu.edu.cn
Z.-P. Zhan, J.-L. Yu, Y.-Y. Cui, R.-F. Yang, W.-Z. Yang, J.-P. Li, J. Org. Chem., 2006, 71, 8298-8301.
DOI: 10.1021/jo061234p (free Supporting Information)
A general and efficient FeCl3-catalyzed substitution reaction of propargylic alcohols with carbon- and heteroatom-centered nucleophiles such as allyl trimethylsilane, alcohols, aromatic compounds, thiols, and amides, forms new C-C, C-O, C-S and C-N bonds.
see article for more examples
M. Lin, L. Hao, X.-t. Liu, Q.-z. Chen, F. Wu, P. Yan, S.-x. Xu, X.-l. Chen, J.-j. Wen, Z.-p. Zhan, Synlett, 2011, 665-670.