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Domino Cu-Catalyzed C-N Coupling/Hydroamidation: A Highly Efficient Synthesis of Nitrogen Heterocycles

Rubén Martín, Marta Rodríguez Rivero, Stephen L. Buchwald*

*Department of Chemistry, Room 18-490, Massachusetts Institute of Technology, Cambridge, MA 02139, USA, Email:

R. Martin, M. R. Rivero, S. L. Buchwald, Angew. Chem. Int. Ed., 2006, 45, 7079-7082.

DOI: 10.1002/anie.200602917

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A general, highly flexible Cu-catalyzed domino C-N coupling/hydroamination reaction constitutes a straightforward alternative to existing methodology for the preparation of pyrroles and pyrazoles.

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Key Words

amidation, copper, domino reactions, hydroamidation, heterocycles, pyrroles, pyrazoles

ID: J06-Y2006-3430