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Simplification of the Mitsunobu Reaction. Di-p-chlorobenzyl Azodicarboxylate: A New Azodicarboxylate

Bruce H. Lipshutz,* David W. Chung, Brian Rich and Ricardo Corral

*Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, Email:

B. H. Lipshutz, D. W. Chung, B. Rich, R. Corral, Org. Lett., 2006, 8, 5069-5072.

DOI: 10.1021/ol0618757 (free Supporting Information)


Solid and stable di-p-chlorobenzyl azodicarboxylate (DCAD) is an alternative to DEAD and DIAD for various Mitsunobu couplings. The hydrazine byproduct from DCAD/Ph3P-mediated reactions can be readily separated and recycled.

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Key Words

Mitsunobu Reaction

ID: J54-Y2006-3470