Simplification of the Mitsunobu Reaction. Di-p-chlorobenzyl Azodicarboxylate: A New Azodicarboxylate
Bruce H. Lipshutz,* David W. Chung, Brian Rich and Ricardo Corral
*Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, Email: lipshutzchem.ucsb.edu
B. H. Lipshutz, D. W. Chung, B. Rich, R. Corral, Org. Lett., 2006, 8, 5069-5072.
DOI: 10.1021/ol0618757 (free Supporting Information)
Solid and stable di-p-chlorobenzyl azodicarboxylate (DCAD) is an alternative to DEAD and DIAD for various Mitsunobu couplings. The hydrazine byproduct from DCAD/Ph3P-mediated reactions can be readily separated and recycled.
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