Highly Enantioselective Transfer Hydrogenation of α,β-Unsaturated Ketones

Nolwenn J. A. Martin and Benjamin List*

*Max-Planck-Institut für Kohlenforschung, D-45470 Mülheim an der Ruhr, Germany, Email: listmpi-muelheim.mpg.de

N. J. A. Martin, B. List, J. Am. Chem. Soc., 2006, 128, 13368-13369.

DOI: 10.1021/ja065708d

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Abstract

An efficient and highly enantioselective conjugate transfer hydrogenation of α,β-unsaturated ketones is catalyzed by a salt made from tert-butyl valinate and a recently introduced powerful chiral phosphoric acid catalyst (TRIP).

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Key Words

Reduction of Enones, Organocatalysis, Hantzsch Ester

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ID: J48-Y2006-3480