Organic Chemistry Portal



Highly Enantioselective Transfer Hydrogenation of α,β-Unsaturated Ketones

Nolwenn J. A. Martin and Benjamin List*

*Max-Planck-Institut für Kohlenforschung, D-45470 Mülheim an der Ruhr, Germany, Email:

N. J. A. Martin, B. List, J. Am. Chem. Soc., 2006, 128, 13368-13369.

DOI: 10.1021/ja065708d


An efficient and highly enantioselective conjugate transfer hydrogenation of α,β-unsaturated ketones is catalyzed by a salt made from tert-butyl valinate and a recently introduced powerful chiral phosphoric acid catalyst (TRIP).

see article for more examples

Key Words

Reduction of Enones, Organocatalysis, Hantzsch Ester

ID: J48-Y2006-3480