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Direct and Efficient One-Pot Preparation of Ketones from Aldehydes Using N-tert-Butylphenylsulfinimidoyl Chloride

James J. Crawford, Kenneth W. Henderson and William J. Kerr*

*Department of Pure and Applied Chemistry, WestCHEM, University of Strathclyde, 295 Cathedral Street, Glasgow, Scotland, U.K. G1 1XL, Email:

J. J. Crawford, K. W. Hederson, W. J. Kerr, Org. Lett., 2006, 8, 5073-5076.

DOI: 10.1021/ol061903l


A range of unsymmetrical ketones has been prepared in good yields from aldehydes in one simple synthetic operation by addition of organolithium compounds followed by an oxidation using N-tert-butylphenylsulfinimidoyl chloride.

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Key Words

Ketones, N-tert-Butylphenylsulfinimidoyl Chloride

ID: J54-Y2006-3490