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Branch-Selective Intermolecular Hydroacylation: Hydrogen-Mediated Coupling of Anhydrides to Styrenes and Activated Olefins

Young-Taek Hong, Andriy Barchuk, Michael J. Krische*

*University of Texas at Austin, Department of Chemistry and Biochemistry, 1 University Station - A5300, Austin, TX, Email:

Y.-T. Hong, A. Barchuk, M. J. Krische, Angew. Chem. Int. Ed., 2006, 45, 6885-6888.

DOI: 10.1002/anie.200602377


A regioselective intermolecular hydroacylation of vinalarenes, in which symmetric and mixed carboxylic anhydrides are used as acyl donors, is promoted by a cationic rhodium catalyst ligated by triphenylarsine.

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Key Words

alkenes, homogeneous catalysis, hydroacylation, hydrogenation, rhodium, ketones, enones

ID: J06-Y2006-3500