Tandem Palladium-Catalyzed Urea Arylation-Intramolecular Ester Amidation: Regioselective Synthesis of 3-Alkylated 2,4-Quinazolinediones
Michael C. Willis,* Robert H. Snell, Anthony J. Fletcher and Robert L. Woodward
*Department of Chemistry, University of Bath, Bath, BA2 7AY, United Kingdom, Email:
m.c.willis
bath.ac.uk
M. C. Willis, R. H. Snell, A. J. Fletcher, R. L. Woodward, Org. Lett., 2006, 8, 5089-5091.
DOI: 10.1021/ol062009x
Abstract
A tandem palladium-catalyzed arylation-ester amidation sequence allows the synthesis of various quinazolinedione products by reaction of o-halo benzoates with monoalkyl ureas. The reactions are regioselective for the formation of 3-N-alkyl isomers.
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Key Words
quinazolinediones, Buchwald-Hartwig Coupling
ID: J54-Y2006-3510
