Single-Step Synthesis of Pyrimidine Derivatives
Mohammad Movassaghi* and Matthew D. Hill
*Massachusetts Institute of Technology, Department of Chemistry, Cambridge,
Massachusetts 02139, Email: movassag
mit.edu
M. Movassaghi, M. D. Hill, J. Am. Chem. Soc., 2006, 128, 14254-14255.
DOI: 10.1021/ja066405m
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Abstract
A single-step conversion of various N-vinyl and N-aryl amides to the corresponding pyrimidine and quinazoline derivatives involves amide activation with 2-chloropyridine and trifluoromethanesulfonic anhydride followed by nitrile addition into the reactive intermediate and cycloisomerization.
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Synthesis of Densely Substituted Pyrimidine Derivatives
O. K. Ahmad, M. D. Hill, M. Movassaghi, J. Org. Chem., 2009, 74, 8460-8463.
Single-Step Synthesis of Pyridine Derivatives
M. Movassaghi, M. D. Hill, O. K. Ahmad, J. Am. Chem. Soc., 2007, 129, 10096-10097.
A Versatile Cyclodehydration Reaction for the Synthesis of Isoquinoline and β-Carboline Derivatives
M. Movassaghi, M. D. Hill, Org. Lett., 2008, 10, 3485-3488.
Key Words
ID: J48-Y2006-3560
