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Single-Step Synthesis of Pyrimidine Derivatives

Mohammad Movassaghi* and Matthew D. Hill

*Massachusetts Institute of Technology, Department of Chemistry, Cambridge, Massachusetts 02139, Email:

M. Movassaghi, M. D. Hill, J. Am. Chem. Soc., 2006, 128, 14254-14255.

DOI: 10.1021/ja066405m

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A single-step conversion of various N-vinyl and N-aryl amides to the corresponding pyrimidine and quinazoline derivatives involves amide activation with 2-chloropyridine and trifluoromethanesulfonic anhydride followed by nitrile addition into the reactive intermediate and cycloisomerization.

see article for more reactions

Synthesis of Densely Substituted Pyrimidine Derivatives

O. K. Ahmad, M. D. Hill, M. Movassaghi, J. Org. Chem., 2009, 74, 8460-8463.

Single-Step Synthesis of Pyridine Derivatives

M. Movassaghi, M. D. Hill, O. K. Ahmad, J. Am. Chem. Soc., 2007, 129, 10096-10097.

A Versatile Cyclodehydration Reaction for the Synthesis of Isoquinoline and β-Carboline Derivatives

M. Movassaghi, M. D. Hill, Org. Lett., 2008, 10, 3485-3488.

Key Words


ID: J48-Y2006-3560