Room Temperature Hydroamination of N-Alkenyl Ureas Catalyzed by a Gold(I) N-Heterocyclic Carbene Complex
Christopher F. Bender and Ross A. Widenhoefer*
*P. M. Gross Chemical Laboratory, Duke University, Durham, North Carolina
27708-0346, Email: rwidenho
chem.duke.edu
C. F. Bender, R. A. Widenhoefer, Org. Lett., 2006, 8, 5303-5305.
DOI: 10.1021/ol062107i
Abstract
Treatment of an N-4-pentenyl or N-5-hexenyl urea with a catalytic 1:1 mixture of a gold(I) N,N-diaryl imidazol-2-ylidine complex and AgOTf gave the corresponding nitrogen heterocycle in excellent yield via an intramolecular exo-hydroamination.
see article for more examples
Gold(I)-Catalyzed Intramolecular Hydroamination of Alkenyl Carbamates
X. Han, R. A. Widenhoefer, Angew. Chem. Int. Ed., 2006, 45, 1747-1749.
Key Words
ID: J54-Y2006-3640
