Mild Zinc-Promoted Horner-Wadsworth-Emmons Reactions of Diprotic Phosphonate Reagents
Douglas J. Schauer, Paul Helquist*
*University of Notre Dame, Department of Chemistry and Biochemistry and
Walther Cancer Research Center, 251 Nieuwland Science Hall, Notre Dame, IN
46556, USA, Email: phelquis
nd.edu
D. J. Schauer, P. Helquist, Synthesis, 2006, 3654-3660.
Abstract
A mild protocol for the Horner-Wadsworth-Emmons reaction of diprotic phosphonates makes use of a zinc triflate promoter in the presence of mild tertiary amine bases to produce α,β-unsaturated carboxylic acids and amides.
see article for more reactions
Key Words
Wittig-Horner Reaction, unsaturated carboxylic acid derivatives, olefinations, zinc
ID: J66-Y2006-3670
