General and Highly Efficient Synthesis of 2-Alkylideneazetidines and β-Lactams via Copper-Catalyzed Intramolecular N-Vinylation
Hongjian Lu and Chaozhong Li*
*Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354
Fenglin Road, Shanghai 200032, PRC, Email: clig
mail.sioc.ac.cn
H. Lu, C. Li, Org. Lett., 2006, 8, 5365-5367.
DOI: 10.1021/ol062274i
Abstract
N-Tosyl-3-halo-3-butenylamines underwent efficient Ullmann-type coupling to afford 2-alkylideneazetidines, which could be readily converted to the corresponding β-lactams by oxidation with O3.
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Q. Zhao, C. Li, Org. Lett., 2008, 10, 4037-4040.
Key Words
Ullmann Coupling, Ozonolysis, Ozone, Azetidines, β-Lactams
ID: J54-Y2006-3680
