A General Method for the Catalytic Nazarov Cyclization of Heteroaromatic Compounds
John A. Malona, Jessica M. Colbourne and Alison J. Frontier*
*Department of Chemistry, University of Rochester, Rochester, New York,
14627, Email: frontier
chem.rochester.edu
J. A. Malona, J. M. Colbourne, A. J. Frontier, Org. Lett., 2006, 8, 5661-5664.
DOI: 10.1021/ol062403v
Abstract
Scandium triflate was identified as the most reactive promoter for efficient catalytic Nazarov cyclization of systems containing heteroaromatic components and it was found that addition of lithium perchlorate was necessary for synthetically useful catalytic cyclizations. The method was used to synthesize a range of cyclopentanone-fused heteroaromatic systems in good yield.
see article for more examples
Cationic Cyclizations and Rearrangements Promoted by a Heterogeneous Gold Catalyst
T. Vaidya, R. Cheng, P. N. Carlsen, A. J. Frontier, R. Eisenberg, Org. Lett., 2014, 16, 800-803.
Key Words
ID: J54-Y2006-3860
