Ruthenium-catalyzed [2 + 2 + 1] Cocyclization of Isocyanates, Alkynes, and CO Enables the Rapid Synthesis of Polysubstituted Maleimides
Teruyuki Kondo,* Masato Nomura, Yasuyuki Ura, Kenji Wada and Take-aki Mitsudo
*Department of Energy and Hydrocarbon Chemistry, Graduate School of
Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan, Email:
teruyuki
scl.kyoto-u.ac.jp
T. Kondo, M. Nomura, Y. Ura, K. Wada, T. Mitsudo, J. Am. Chem. Soc., 2006, 128, 14816-14817.
DOI: 10.1021/ja066305g
Abstract
Intermolecular [2 + 2 + 1] ruthenium-catalyzed cocyclization of isocyanates, alkynes, and CO proceeded smoothly in mesitylene at 130°C to give a variety of polysubstituted maleimides in excellent yields with high selectivity.
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Key Words
Maleimides, Multicomponent Reactions
ID: J48-Y2006-3880
