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Regioselective Synthesis of Substituted Pyrroles: Efficient Palladium-Catalyzed Cyclization of Internal Alkynes and 2-Amino-3-iodoacrylate Derivatives

Matthew L. Crawley,* Igor Goljer, Douglas J. Jenkins, John F. Mehlmann, Lisa Nogle, Rebecca Dooley and Paige E. Mahaney

*Discovery Medicinal Chemistry and Discovery Analytical Chemistry, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, Email:

M. L. Crawley, I. Goljer, D. J. Jenkins, J. F. Mehlmann, L. Nogle, R. Dooley, P. E. Mahaney, Org. Lett., 2006, 8, 5837-5840.

DOI: 10.1021/ol062424p (free Supporting Information)


An efficient and regioselective palladium-catalyzed cyclization of internal alkynes and 2-amino-3-iodoacrylates gave good yields of highly functionalized pyrroles.

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ID: J54-Y2006-3920