Controlling Regiochemistry in Negishi Carboaluminations. Fine Tuning the Ligand on Zirconium
Bruce H. Lipshutz,* Tom Butler and Asher Lower
*Department of Chemistry & Biochemistry, University of California, Santa
Barbara, California 93106, Email: lipshutz
chem.ucsb.edu
B. H. Lipshutz, T. Butler, A. Lower, J. Am. Chem. Soc., 2006, 128, 15396-15398.
DOI: 10.1021/ja065769b
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Abstract
Use of a zirconocene catalyst based on the Brintzinger ligand and catalytic amounts of methyl aluminoxanes (MAO) effect a >99% regiocontrol of Negishi carboaluminations of 1-alkynes in toluene.
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Key Words
Negishi carboalumination, alkenes, bromination, allylic alcohols
ID: J48-Y2006-3930
