An Efficient Base-Free N-Arylation of Imidazoles and Amines with Arylboronic Acids Using Copper-Exchanged Fluorapatite
M. Lakshmi Kantam,* Gopaldasu T. Venkanna, Chidara Sridhar, Bojja Sreedhar and Boyapati M. Choudary
*Inorganic and Physical Chemistry Division, Indian Institute of Chemical Technology, Hyderabad 500 007, India, E-mail: mlakshmiiict.res.in
M. L. Kantam, G. T. Venkanna, C. Sridhar, B. Sreedhar, B. M. Choudary, J. Org. Chem., 2006, 71, 9522-9524.
N-Arylation of imidazoles and amines with arylboronic acids catalyzed by copper-exchanged fluorapatite (CuFAP) in methanol at room temperature gave N-arylimidazoles and N-arylamines in good yields. The use of various arylboronic acids demonstrated the versatility of the reaction.
see article for more examples
Copper(I) Oxide Catalyzed N-Arylation of Azoles and Amines with Arylboronic Acid at Room Temperature under Base-Free Conditions
B. Sreedhar, G. T. Venkanna, K. B. S. Kumar, V. Balasubrahmanyam, Synthesis, 2008, 795-799.
Chan-Lam Coupling, Arylation (Heterocycles, Anilines)