An Efficient Base-Free N-Arylation of Imidazoles and Amines with Arylboronic Acids Using Copper-Exchanged Fluorapatite
M. Lakshmi Kantam,* Gopaldasu T. Venkanna, Chidara Sridhar, Bojja Sreedhar and Boyapati M. Choudary
*Inorganic and Physical Chemistry Division, Indian Institute of Chemical
Technology, Hyderabad 500 007, India, E-mail:
mlakshmiiict.res.in
M. L. Kantam, G. T. Venkanna, C. Sridhar, B. Sreedhar, B. M. Choudary, J. Org. Chem., 2006, 71, 9522-9524.
DOI: 10.1021/jo0614036
Abstract
N-Arylation of imidazoles and amines with arylboronic acids catalyzed by copper-exchanged fluorapatite (CuFAP) in methanol at room temperature gave N-arylimidazoles and N-arylamines in good yields. The use of various arylboronic acids demonstrated the versatility of the reaction.
see article for more examples
B. Sreedhar, G. T. Venkanna, K. B. S. Kumar, V. Balasubrahmanyam, Synthesis, 2008, 795-799.
Key Words
Chan-Lam Coupling, Arylation (Heterocycles, Anilines)
ID: J42-Y2006-3950