One-Step Conversion of Pyridine N-Oxides to Tetrazolo[1,5-a]pyridines
John M. Keith*
*Johnson & Johnson Pharmaceutical Research & Development, L.L.C. 3210 Merryfield Row, San Diego, California 92121, E-mail: jkeithprdus.jnj.com
J. M. Keith, J. Org. Chem., 2006, 71, 9540-9543.
DOI: 10.1021/jo061819j
Abstract
Pyridine N-oxides were converted to tetrazolo[1,5-a]pyridines in good yield in the presence of sulfonyl or phosphoryl azides and pyridine by heating in the absence of solvent. Diphenyl phosphorazidate (DPPA) was the most convenient reagent.
see article for more examples
Key Words
ID: J42-Y2006-3990