Organic Chemistry Portal



Synthesis of N-Substituted Indole Derivatives via PIFA-Mediated Intramolecular Cyclization

Yunfei Du, Renhe Liu, Gregory Linn and Kang Zhao*

*College of Pharmaceuticals and Biotechnology, Tianjin University, 300072, PRC, Email:

Y. Du, R. Liu, G. Linn, K. Zhao, Org. Lett., 2006, 8, 5919-5922.

DOI: 10.1021/ol062288o

see article for more reactions


Various N-arylated and N-alkylated indoles and pyrrole-fused aromatic compounds were synthesized by a phenyliodine bis(trifluoroacetate) (PIFA)-mediated intramolecular cyclization.

see article for more examples

Key Words

indoles, PIFA

ID: J54-Y2006-4010