Suzuki-Miyaura Cross-Coupling Reactions of Potassium Vinyltrifluoroborate with Aryl and Heteroaryl Electrophiles
Gary A. Molander* and Adam R. Brown
*Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, E-mail: gmolandrsas.upenn.edu
G. A. Molander, A. R. Brown, J. Org. Chem., 2006, 71, 9681-9686.
DOI: 10.1021/jo0617013 (free Supporting Information)
The palladium-catalyzed cross-coupling reaction of potassium vinyltrifluoroborate with aryl electrophiles can generally be effected using 2 mol % of PdCl2 and 6 mol % of PPh3 as a catalyst system in THF/H2O with Cs2CO3 as a base. Good yields are obtained in the presence of various functional groups.
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G. A. Molander, C. R. Bernardi, J. Org. Chem., 2002, 67, 8424-8429.