Heterogeneous Copper-in-Charcoal-Catalyzed Click Chemistry
Bruce H. Lipshutz*, Benjamin R. Taft
*Department of Chemistry and Biochemistry, University of California, Santa Barbara, Santa Barbara, CA 93106-9510, USA, Email: lipshutzchem.ucsb.edu
B. H. Lipshutz, B. R. Taft, Angew. Chem. Int. Ed., 2006, 45, 8235-8238.
DOI: 10.1002/anie.200603726 (free Supporting Information)
Highly efficient click chemistry between azides and terminal alkynes can be heterogeneously catalyzed by copper nanoparticles mounted within the pores of activated charcoal. Reactions can be accelerated with stoichiometric Et3N or by increasing the reaction temperature using microwave irradiation.
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