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Cu(I) Tol-BINAP-Catalyzed Enantioselective Michael Reactions of Grignard Reagents and Unsaturated Esters

Shun-Yi Wang, Shun-Jun Ji and Teck-Peng Loh*

*Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 639798, Email: teckpengntu.edu.sg

S.-Y. Wang, S.-J. Ji, T.-P. Loh, J. Am. Chem. Soc., 2007, 129, 276-277.

DOI: 10.1021/ja0666046


Abstract

A highly efficient regio- and enantioselective catalytic asymmetric addition of Grignard regeants to α,β-unsaturated esters is promoted by the CuI-Tol-BINAP system.


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Key Words

Conjugate Additions


ID: J48-Y2007-0000