Aluminum Iodide Promoted Highly Z-Stereoselective Synthesis of β-Iodo Morita-Baylis-Hillman Esters with Ketones as Aldol Acceptors
Sung Il Lee, Geum-Sook Hwang, Do Hyun Ryu*
*Department of Chemistry, Sungkyunkwan University, Suwon 440-746, Korea, Email: dhryuskku.edu
S. Il Lee, G.-S. Hwang, D. H. Ryu, Synlett, 2007, 59-62.
Various ketones as the electrophiles react in a one pot three-component coupling with an aluminum allenoate intermediate derived from ethyl propiolate and alluminium iodide to yield β-iodo Morita-Baylis-Hillman adducts with high yield and excellent Z-stereoselectivity.
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