Convenient Synthetic Approach to 2,4-Disubstituted Quinazolines
Serena Ferrini, Fabio Ponticelli and Maurizio Taddei*
*Dipartimento di Chimica and Dipartimento Farmaco Chimico Tecnologico,
Università degli Studi di Siena, Via A. Moro, 53100 Siena, Italy, Email:
taddei.m
unisi.it
S. Ferrini, F. Ponticelli, M. Taddei, Org. Lett., 2007, 9, 69-72.
DOI: 10.1021/ol062540s
Abstract
A photochemically induced Fries rearrangement of anilides gave several ortho-aminoacylbenzene derivatives that were acylated. These acylamides underwent rapid microwave-assited cyclization to 2,4-disubstituted quinazolines (and benzoquinazolines) in the presence of ammonium formate.
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proposed mechanism
Key Words
Quinozalines, Fries Rearrangement, Microwave Synthesis
ID: J54-Y2007-0090
