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Vanadium-Catalyzed Asymmetric Epoxidation of Homoallylic Alcohols

Wei Zhang and Hisashi Yamamoto*

*Department of Chemistry, University of Chicago, 5735 South Ellis Avenue, Chicago, Illinois 60637, Email:

W. Zhang, H. Yamamoto, J. Am. Chem. Soc., 2007, 129, 286-287.

DOI: 10.1021/ja067495y


Chiral bishydroxamic acid ligands provided good yields and high enantioselectivities in the vanadium-catalyzed asymmetric epoxidation of homoallylic alcohols.

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Enantioselective Epoxidation of Allylic Alcohols by a Chiral Complex of Vanadium: An Effective Controller System and a Rational Mechanistic Model

W. Zhang, A. Basak, Y. Kosugi, Y. Hoshino, H. Yamamoto, Angew. Chem. Int. Ed., 2005, 44, 4389-4391.

Key Words

asymmetric catalysis, chirality, epoxidation, ligand design, vanadium, cumene hydroperoxide

ID: J48-Y2007-0100