Three-Component Coupling Reactions of Thioformamides with Organolithium and Grignard Reagents Leading to Formation of Tertiary Amines and a Thiolating Agent
Toshiaki Murai* and Fumio Asai
*Department of Chemistry, Faculty of Engineering, Gifu University, Yanagido, Gifu 501-1193, Japan, Email: mtoshigifu-u.ac.jp
T. Murai, F. Asai, J. Am. Chem. Soc., 2007, 129, 780-781.
A highly efficient three-component coupling reaction between thioformamides and organolithium and Grignard reagents was developed. The generality of the process has been demonstrated by using various combinations of reactants and reagents.
see article for more examples
Sequential Addition Reactions of Two Molecules of Grignard Reagents to Thioformamides
T. Murai, K. Ui, Narengerile, J. Org. Chem., 2009, 74, 5703-5706.
Amines, Benzylamines, Grignard Reagents