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Three-Component Coupling Reactions of Thioformamides with Organolithium and Grignard Reagents Leading to Formation of Tertiary Amines and a Thiolating Agent

Toshiaki Murai* and Fumio Asai

*Department of Chemistry, Faculty of Engineering, Gifu University, Yanagido, Gifu 501-1193, Japan, Email:

T. Murai, F. Asai, J. Am. Chem. Soc., 2007, 129, 780-781.

DOI: 10.1021/ja068523f


A highly efficient three-component coupling reaction between thioformamides and organolithium and Grignard reagents was developed. The generality of the process has been demonstrated by using various combinations of reactants and reagents.

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Sequential Addition Reactions of Two Molecules of Grignard Reagents to Thioformamides

T. Murai, K. Ui, Narengerile, J. Org. Chem., 2009, 74, 5703-5706.

Key Words

Amines, Benzylamines, Grignard Reagents

ID: J48-Y2007-250