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A Novel and Efficient Synthesis of Unsymmetrical Disulfides

Sylwia Antoniow, Dariusz Witt*

*Department of Organic Chemistry, Chemical Faculty, Gdansk University of Technology, Narutowicza 11/12, 80-952 Gdansk, Poland, Email:

S. Antoniow, D. Witt, Synthesis, 2007, 363-366.

DOI: 10.1055/s-2007-965873


Unsymmetrical disulfides have been prepared from the corresponding thiols and bis-(5,5-dimethyl-2-thiono-1,3,2-dioxa­phosphorinanyl)disulfide under mild conditions with very good yields. This method can be applied to thiols bearing neutral, aromatic, basic or acidic functionalities with variable length of carbon chain.

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Functionalization of Cysteine Derivatives by Unsymmetrical Disulfide Bond Formation

M. Szymelfejnik, S. Demkowicz, J. Rachon, D. Witt, Synthesis, 2007, 3528-3534.

Novel and Efficient Methods for the Synthesis of Symmetrical Trisulfides

A. Kertmen, S. Lach, J. Rachon, D. Witt, Synthesis, 2009, 1459-1462.

Key Words

disulfides, alkanethiols, l-cysteine, thiophenol

ID: J66-Y2007-0290