Octanol-Accelerated Baylis-Hillman Reaction
Kwang-Su Park, Jinyoung Kim, Hyunah Choo, Youhoon Chong*
*Department of Bioscience and Biotechnology, Institute of Biomedical Science and Technology, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 143-701, Korea, Email: chongykonkuk.ac.kr
K.-S. Park, J. Kim, H. Choo, Y. Chong, Synlett, 2007, 395-398.
The use of octanol as an additive greatly accelerated the Baylis-Hillman reaction and allowed the conversion of unactivated aldehydes such as aliphatic aldehydes and aromatic aldehydes with electron-withdrawing substituents into Baylis-Hillman adducts in very good yields.
see article for more reactions
Baylis-Hillman reaction, octanol, additive, rate acceleration, aliphatic aldehydes