General and Direct Synthesis of 3-Aminoindolizines and Their Analogues via Pd/Cu-Catalyzed Sequential Cross-Coupling/Cycloisomerization Reactions
Yuanhong Liu,* Zhiquan Song and Bin Yan
*State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, People's Republic of China, Email: yhliumail.sioc.ac.cn
Y. Liu, Z. Song, B. Yan, Org. Lett., 2007, 9, 409-412.
DOI: 10.1021/ol062766v
Abstract
An efficient and one-step synthesis of 3-aminoindolizines or benz[e]indolizines from the reactions of propargyl amines or amides with heteroaryl bromides is realized by a tandem reaction using Pd/Cu catalysts, which catalyze coupling and cycloisomerization reactions in the same vessel.
see article for more reactions
B. Yan, Y. Liu, Org. Lett., 2007, 9, 4323-4326.
B. Yan, Y. Zhou, H. Zhang, J. Chen, Y. Liu, J. Org. Chem., 2007, 72, 7783-7786.
Key Words
Indolizines, Sonogashira Coupling
ID: J54-Y2007-0350