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An Extremely Efficient Three-Component Reaction of Aldehydes/Ketones, Amines, and Phosphites (Kabachnik-Fields Reaction) for the Synthesis of α-Aminophosphonates Catalyzed by Magnesium Perchlorate

Srikant Bhagat and Asit K. Chakraborti*

*Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S. A. S. Nagar 160 062, Punjab, India, Email:

S. Bhagat, A. K. Chakraborti, J. Org. Chem., 2007, 72, 1263-1270.

DOI: 10.1021/jo062140i (free Supporting Information)

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Magnesium perchlorate is an efficient catalyst for the three-component reaction of amines, aldehydes or ketones, and di-/trialkyl phosphites (Kabachnik-Fields reaction) under solvent-free conditions to afford the corresponding α-aminophosphonates in high yields. Using Mg(ClO4)2 as catalyst, no imines or α-hydroxy phosphonates were observed as intermediates.

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Key Words

Kabachnik-Fields Reaction, α-Amino Phosphonates, Multicomponent Reactions

ID: J42-Y2007-0460