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Palladium-Catalyzed Aryl-Aryl Cross-Coupling Reaction Using ortho-Substituted Arylindium Reagents

Miguel A. Pena, José Pérez Sestelo* and Luis A. Sarandeses*

*Departamento de Química Fundamental, Universidade da Coruña, E-15071 A Coruña, Spain, Email:,

M. A. Pena, J. P. Sestelo, L. A. Sarandeses, J. Org. Chem., 2007, 72, 1271-1275.

DOI: 10.1021/jo062148s

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A range of biaryl compounds can be efficiently prepared in high yields by a palladium-catalyzed cross-coupling reaction between ortho-substituted triarylindium reagents and aryl halides. The triarylindium reagents are prepared by directed ortho-lithiation and transmetallation to indium from the corresponding benzene derivatives.

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Palladium-Catalyzed Cross-Coupling Reactions of Triorganoindium Compounds with Vinyl and Aryl Triflates or Iodides

I. Pérez, J. P. Sestelo, L. A. Sarandeses, Org. Lett., 1999, 1, 1267-1269.

Key Words

directed ortho metalation, biaryls, heterobiaryls, indoles

ID: J42-Y2007-0480