Catalytic Asymmetric Alkylation of α-Cyanocarboxylates Using a Phase-Transfer Catalyst
Kazuhiro Nagata, Daisuke Sano, Takashi Itoh*
*School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai,
Shinagawa-ku, Tokyo 142-8555, Japan, Email: itoh-t
pharm.showa-u.ac.jp
K. Nagata, D. Sano, T. Itoh, Synlett, 2007, 547-550.
DOI: 10.1055/s-2007-967963
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Abstract
A highly enantioselective catalytic alkylation of cyanoacetates was achieved using a chiral phase-transfer catalyst to give α,α-disubstituted α-cyanoacetates which have a chiral quaternary carbon.
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Key Words
organocatalysis, phase-transfer catalysis, asymmetric synthesis, alkylation, allylation, benzylations, halides
ID: J60-Y2007-0550
