Catalytic Asymmetric Alkylation of α-Cyanocarboxylates Using a Phase-Transfer Catalyst
Kazuhiro Nagata, Daisuke Sano, Takashi Itoh*
*School of Pharmaceutical Sciences, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo 142-8555, Japan, Email: itoh-tpharm.showa-u.ac.jp
K. Nagata, D. Sano, T. Itoh, Synlett, 2007, 547-550.
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A highly enantioselective catalytic alkylation of cyanoacetates was achieved using a chiral phase-transfer catalyst to give α,α-disubstituted α-cyanoacetates which have a chiral quaternary carbon.
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